Comparison of laparoscopic and open simultaneous surgeries for synchronous metastases of colorectal cancer in the liver: meta-analysis

Aim. To analyze studies focused on comparing laparoscopic and open simultaneous surgeries for synchronous metastases of colorectal cancer in the liver. Materials methods. The electronic databases PubMed, Web Science, Scopus, Embase, Cochrane Library were searched comparison metastatic liver lesions, dated till October 20, 2020. Keywords: resections, cancer, metastases, laparoscopic. Results. Meta-analysis contains results 1211 liver: 450 761 surgeries. Laparoscopic surgery was characterized with lower blood loss [weighted mean difference (WMD) = -131.77, 95% CI: -232.54 to -31.00, p 0.01], a shorter postoperative hospitalization [WMD -2.87, -3.41 -2. 33, < 0.00001], early first bowel movement -0.99, -1.40 -0.58, 0.0001], initiation enteral feeding -1.20, -2.06 -0.33, 0.007]), incidence complications [OR 0.60, 0.46–0.80, 0.0004]. A statistically significant advantage access established overall 0.80, 0.64–0.99, 0.04] recurrence-free survival 0.73, 0.60–0.89, 0.002]. Conclusion. Perioperative distant oncologic outcomes demonstrate safety efficacy interventions interventions.